Got something to add:
I recommend going 5/5 Toughness for the slow reduction or 3/5 Toughness 2/3 Annihilation if you want to be more offensive. Haste wont help that much really unless you have SM/Bryntroll, and even then the difference isnt big.
Also Id go 2xEpidemic and drop a point in Impurity for Corpse Explo.
You should note that these 2 points in Pale Horse are optional, which means that you have a choice between IUP, OPH, CotG and WP.
Glyph of Disease is the best imo, cause instead of x2 runes you use 1 blood, allowing you to death strike/coi or whatever.
Glyph of Corpse explosion works only when you blow up npc corpses, not your pet. It's useless.
As for the items and gems, you have some more options as well:
You can use Persistent meta gem for 10% stun reduction. I think thats half a sec from HoJ, and if youre orc + On a Pale Horse = cool reduction.
If you want to go more offensive you can put 20 str gems in sockets which give you crit/haste/exp socket bonuses.
As for the items, Skeleton Lord is good because unlike how Wrath ring gives you AP you get Str instead. Same goes for the back/neck slots, however its better to use Ahn Kahar neck from 25man lady and Garroshs Rage from ToC 25 man is pretty much equal cause crit isnt much better then haste.
OR
You could use wrath ring/back/neck for more resi. Bryntroll is a good pve weapon to pair them with, keeping resi high.