Sure can, but there is nothing that frost can do better than blood in 25hc setting. Unbreakable armor is so meh, that you will need external CD, which raid may not even have because it's already spent on reapers and such. Bigger threat is not a selling point either, as rogues and hunters will do their job in 25hc.
As said in guide, Keleseth is good to tank with frost, tough I disagree. Adds on LDW is nothing that blood couldn't handle. Acclimation might be great and all, but there really is no threat of dying from "auto" damage, threat comes when Kele gets his Empowered and then you are lacking one cd. It will stack up nicely on Sindra, but dual wielding will make you take stacks fast, don't think that's better in any way, tough breaths and blisterings will be kind of dampened(-10%?), but I rather have that vamp blood that just works instead of unbreakeble armor. What you realisticaly will have is reached 340 resistance - that provides guaranteed 30% resists. I doubt its worth to use resist gear to reach for 510 resistance for those 40% guaranteed resists. I really doubt its worth the pain. Especialy the fact that you can get those 219 resistance on blood for guaranteed 20% resisted.
I'd spare myself, healers and everyone in raid and just go blood for endgame. But it sure can be done.