20% to hots
or 25% spell power from int?
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I'll try and guess that you're asking for TBC, whether to go for Lunar Guidance or Empowered Rejuvenation for.. better healing?
Go for Emp. Reju. (20% to hots) and with it take Tree of Life (healing received increased by 25% of spirit).
Lunar guidance is an interesting choice, but in order for it to be better for healing than the other option, you would need some special gear (stats) setup which isn't really worth it.
If this wasn't what you were asking, then I'm sorry, at least i tried. :)