disc or holy

Should i go disc or holy with all gear 264+ lv with spirit + hc antonidas?

Both are great. Holy is harder to play. As a consequence, Disc is more popular (and
that Power Infusion is a dps boost to casters, so they want it, naturally). Really depends on what your guild needs, what you're good at, etc. Personally, I like to keep both available to me most of the time.